Chloroform → HCID 44223336, compound

Participants

Reaction Steps

N-(3-chloro-2-(3-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2,6-difluoro-3-(propylsulfonamido)benzamide (38%) was prepared according to Example 25, substituting N-chlorosuccinimide for N-bromosuccinimide, DMF for CHCl3, and N-(2-(3-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2,6-difluoro-3-(propylsulfonamido)benzamide for 2,6-difluoro-N-(2-phenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-3-(propylsulfonamido)benzamide. 1H NMR (400 MHz, DMSO-d6) δ 12.55 (s, 1H), 11.11 (s, 1H), 9.82 (s, 1H), 8.49-8.46 (m, 2H), 8.01-7.99 (m, 1H), 7.96-7.93 (m, 1H), 7.63-7.52 (m, 3H), 7.32-7.26 (m, 1H), 3.16-3.11 (m, 2H), 1.82-1.74 (m, 2H), 1.03-0.98 (m, 3H); m/z (APCI-pos) M+1=539.0.

Provenance & Evidence