1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 67155879, compound

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Reaction Steps

3-Iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-5-amine (0.506 g, 1.27 mmol), 2,6-difluoro-3-(propylsulfonamido)benzoic acid (0.389 g, 1.39 mmol), EDCI (0.267 g, 1.39 mmol) and HOBt (0.188 g, 1.39 mmol) were dissolved in DMF (10 mL) and stirred at room temperature overnight. The organic portion was washed with water (3×), brine, dried over Na2SO4 and concentrated. The resulting residue was purified by column chromatography (1:1:1 hexane/Et2O/DCM) giving 2,6-difluoro-N-(3-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-3-(propylsulfonamido)benzamide (0.738 g, 88.2%).

Provenance & Evidence