HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2196671Generated: October 25, 2026
Potassium tert-butoxide → 5-nitro-2-phenyl-1H-pyrrolo[2,3-b]pyridine
https://huagongshe.com/reaction/2196671
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Reactant | 5-Nitro-3-(phenylethynyl)pyridin-2-amine | HCID 59322901 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 5-nitro-2-phenyl-1H-pyrrolo[2,3-b]pyridine | HCID 59322900 | 45.2% |
Reaction Steps
A solution of 5-nitro-3-(phenylethynyl)pyridin-2-amine (356 mg, 1.0 eq.) in NMP (6 mL) was treated with KOt-Bu (2.2 eq.), and the solution was heated to 90° C. for 48 hours. The reaction mixture was purified directly by silica gel chromatography (eluting with a gradient of 100% hexanes to 40% EtOAc/hexanes) to afford 5-nitro-2-phenyl-1H-pyrrolo[2,3-b]pyridine (161 mg, 45%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08338452B2 |
|---|
| Source dataset | uspto-grants-2012_12 |
|---|
| ORD ID | ord-93c9ffa6f50b4bd6871a7c832dfd7ad7 |
|---|
| Source note | uspto-grants-2012_12 |
|---|
