Potassium Carbonate → HCID 44223673, compound

Participants

Reaction Conditions

Reaction Steps

2N K2CO3 (1 mL) was added to a solution of 2,6-difluoro-N-(2-(1-methyl-1H-indol-5-yl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-3-(propylsulfonamido)benzamide (19 mg, 29 mmol) in MeOH (3 mL), and the mixture was heated to 60° C. for 16 hours. The volatiles were removed under reduced pressure, and the resulting residue was partitioned between EtOAc and water. The layers were separated, and the organic layers were dried (MgSO4), filtered and concentrated. Dichloromethane was added to the residue, and the resulting solid was collected by vacuum filtration giving 2,6-difluoro-N-(2-(1-methyl-1H-indol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-3-(propylsulfonamido)benzamide (10 mg, 66%). 1H NMR (400 MHz, DMSO-d6) δ 12.04 (s, 1H), 10.84 (s, 1H), 9.80 (s, 1H), 8.33-8.28 (m, 2H), 8.15 (s, 1H), 7.77-7.73 (m, 1H), 7.57-7.52 (m, 2H), 7.39-7.38 (m, 1H), 7.29-7.25 (m, 1H), 6.86 (s, 1H), 6.50-6.49 (m, 1H), 3.83 (s, 3H), 3.15-3.11 (m, 2H), 1.83-1.73 (m, 2H), 1.03-0.98 (m, 3H); m/z (APCI-neg) M−1=522.2.

Provenance & Evidence