HCID 67156041, compound → HCID 67155778, compound

HRID 2196681Notes

Reaction equation

HRID 2196681 reaction equation
[C:1]1([C:7]2[C:15]3[C:10](=[N:11][CH:12]=[C:13]([NH:16][C:17](=[O:33])[C:18]4[C:23]([F:24])=[CH:22][CH:21]=[C:20]([NH:25][S:26]([CH2:29][CH2:30][CH3:31])(=[O:28])=[O:27])[C:19]=4[F:32])[CH:14]=3)[N:9](S(C3C=CC=CC=3)(=O)=O)[CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]=1>CO>[C:1]1([C:7]2[C:15]3[C:10](=[N:11][CH:12]=[C:13]([NH:16][C:17](=[O:33])[C:18]4[C:23]([F:24])=[CH:22][CH:21]=[C:20]([NH:25][S:26]([CH2:29][CH2:30][CH3:31])(=[O:28])=[O:27])[C:19]=4[F:32])[CH:14]=3)[NH:9][CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]=1

Participants

3

Reactant 1

HCID 67156041HCID 67156041, compound

Product 1

HCID 67155778HCID 67155778, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

N-(3-cyclohexenyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2,6-difluoro-3-(propylsulfonamido)benzamide was subjected to methanol/2M aqueous potassium carbonate (1 mg/1 mL) at 60° C. for 1 hour to give N-(3-cyclohexenyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2,6-difluoro-3-(propylsulfonamido)benzamide (100%). m/z (APCI-neg) M−1=473.2, (APCI-pos) M+1=475.1.

Sources & evidence

ORD record
ord-338b2634b8f74a28bd40f6b303189b5f
Source dataset
uspto-grants-2012_12
Patent number
US08338452B2

Reaction notes

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