Diisopropylethylamine → HCID 56675558, compound

Participants

Reaction Steps

A 5 mL flask was charged with 5-amino-2,6-difluoro-(3H-imidazo[4,5-b]pyridin-6-yl)benzamide (30 mg, 0.1 mmol), cyclopropyl sulfonyl chloride (10 mg, 0.1 mmol) and diisopropylethylamine (40 μL) in CH2Cl2 (1 mL). This mixture was stirred at room temperature for 16 hours. The reaction mixture was then diluted with brine, extracted with EtOAc (2×), extracts washed with water (1×), dried over sodium sulfate and concentrated under reduced pressure. The resulting crude product was purified via silica gel chromatography using an ISCO system (10% MeOH/DCM) to give the title compound (14 mg, 30%). m/z (LC-MS) M+1=393.

Provenance & Evidence