HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-[4-(aminomethyl)pyridin-2-yl]methanesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | N-(4-cyanopyridin-2-yl)-methanesulfonamide | HCID 69122739 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-[4-(aminomethyl)pyridin-2-yl]methanesulfonamide | HCID 68521300 | 98.1% |
Reaction Steps
N-(4-Cyano-pyridin-2-yl)-methanesulfonamide (0.15 g, 0.76 mmol) is dissolved in MeOH (4 mL) and concentrated HCl (2 mL) and is treated with Pd/C (10%, 150 mg). The mixture is stirred under H2 for 12 hours, filtered and concentrated in vacuo to afford N-(4-aminomethyl-pyridin-2-yl)-methanesulfonamide (0.15 g, 97%), which is used directly in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08202863B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-7a05c30b23274f788d64a99fce16e740 |
| Source note | uspto-grants-2012_06 |