HCID 66887603, compound → HCID 67155644, compound

Participants

Reaction Steps

N-(3-Ethoxy-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2,6-difluoro-3-(propylsulfonamido)benzamide was prepared following Example 32, Step D, substituting 3-ethoxy-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-amine for 3-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-5-amine. N-(3-Ethoxy-1-tosyl-1H-pyrrolo[2,3-b]pyridin-5-yl)-2,6-difluoro-3-(propylsulfonamido)benzamide was then subjected to methanol/aqueous potassium carbonate at 60° C. for 1 hour to give N-(3-ethoxy-1H-pyrrolo[2,3-b]pyridin-5-yl)-2,6-difluoro-3-(propylsulfonamido)benzamide (30%). 1H NMR (400 MHz, d6-DMSO) δ 11.03 (s, 1H), 10.83 (s, 1H), 8.31-8.35 (m, 2H), 7.10-7.54 (m, 2H), 7.05 (s, 1H), 4.00-4.06 (m, 2H), 3.00-3.06 (m, 2H), 1.70-1.76 (m, 2H), 1.36-1.40 (m, 3H), 0.94-1.01 (m, 3H); (APCI-pos) M+1=439.1 (APCI-pos) M+1=439.1.

Provenance & Evidence