Dimethylamine → HCID 67156401, compound

Participants

Reaction Conditions

Reaction Steps

2,6-Difluoro-N-(2-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-3-(propylsulfonamido)benzamide (0.050 g, 0.076 mmol) and 7.9M dimethylamine in water (0.240 mL) were combined in 1,4-dioxane (0.500 mL). The solution was heated at 100° C. for 18 hours in a sealed vessel. The reaction mixture was concentrated and purified via reverse phase chromatography to give N-(2-(dimethylamino)-1H-pyrrolo[2,3-b]pyridin-5-yl)-2,6-difluoro-3-(propylsulfonamido)benzamide (5.9 mg, 18% yield) as a solid. 1H NMR (400 MHz, d6-DMSO) δ 11.00 (s, 1H), 10.54 (s, 1H), 8.32 (s, 2H), 8.01 (d, 1H), 7.81 (d, 1H), 7.40 (m, 1H), 7.05 (m, 1H), 5.28 (s, 1H), 2.91 (s, 6H), 1.73 (m, 2H), 0.97 (m, 3H). m/z (API-pos) 438.2.

Provenance & Evidence