Water → HCID 67155782, compound

Participants

Reaction Conditions

Reaction Steps

Sodium hydroxide (1.11 mL, 1.11 mmol, 1M in water) was added to a solution of N,N-dimethyl-1-(5-nitro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)methanamine (0.10 g, 0.28 mmol) in THF (1.5 mL). The reaction mixture was heated at 70° C. for 16 hours. The reaction mixture was then cooled down and treated with water and ethyl acetate. The layers were then separated. The aqueous layer was extracted once with ethyl acetate. The organic layers were dried over sodium sulfate, filtered, and evaporated to afford N,N-dimethyl-1-(5-nitro-1H-pyrrolo[2,3-b]pyridin-2-yl)methanamine (0.05 g, 82%).

Provenance & Evidence