Water → HCID 67155969, compound

Participants

Reaction Conditions

Reaction Steps

Sodium tetrahydroborate (0.069 g, 1.81 mmol) was added to a solution of 5-nitro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-2-carbaldehyde (200 mg, 0.60 mmol) in THF (3.8 mL) and methanol (0.4 mL) at −40° C. The mixture was stirred at −40° C. for 30 minutes. The reaction mixture was then treated with water and ethyl acetate, and the layers were separated. The aqueous layer was extracted once with ethyl acetate. The organic layers were dried with sodium sulfate, filtered and concentrated in vacuo. The crude material was purified by flash chromatography to afford (5-nitro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-2-yl)methanol (0.13 g, 65%).

Provenance & Evidence