Lithium Hydroxide → HCID 16665944, compound

Participants

Reaction Steps

A solution of 6-[(2-phenyl-pyrimidin-5-carbonyl)-amino]-1H-benzoimidazole-2-carboxylic acid methyl ester (0.44 mmol) and LiOH (4.40 mmol) in MeOH/water/tetrahydrofuran (1:1:1, 60 mL) is stirred at room temperature overnight. MeOH and THF are evaporated in vacuo and the aqueous mixture is acidified with 5% HCl to pH ˜2. The resulting precipitate is filtered, washed with water (10 mL) and dried to give 6-[(2-phenyl-pyrimidin-5-carbonyl)-amino]-1H-benzoimidazole-2-carboxylic acid as a solid (115 mg). MS: 360 (M+H); 1H NMR (300 MHz, DMSO-d6): δ 7.52-7.70 (m, 5H), 8.30 (s, H), 8.48 (m, 3H), 9.28 (S, H), 9.38 (s, 2H), 10.73 (s, N—H).

Provenance & Evidence