HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(4-(Cyclohexylmethyl)-4-methoxypiperidin-1-yl)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 4-(4-(cyclohexylmethyl)-4-methoxypiperidin-1-yl)benzoate | HCID 16109132 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-(4-(Cyclohexylmethyl)-4-methoxypiperidin-1-yl)benzoic acid | HCID 67144712 | — |
Reaction Steps
A solution of EXAMPLE 1G (300 mg) in dioxane (5 mL) was treated with 1N NaOH (2 mL), stirred overnight, acidified with 1N HCl, extracted with ethyl acetate (3×), dried (MgSO4), and filtered. Concentration of the filtrate gave the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08338466B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-84d02c63b323489988f58f5b2de83eab |
| Source note | uspto-grants-2012_12 |