反应详情

温度

80 °C

A suspension of EXAMPLE 4C (13.0 g, 29.9 mmol) and LiOH monohydrate (3.78 g, 90.0 mmol) in dioxane (250 mL) and water (100 mL) was heated at 95° C. for 16 hours, concentrated to dryness, treated with water (600 mL), heated to 80° C., and filtered. The filtrate was treated with 1M HCl (90 mL) and the resulting precipitate was collected by filtration and dried to give the desired product.

1. concentrationconcentrated to dryness
2. additiontreated with water (600 mL)
3. filtrationfiltered
4. additionThe filtrate was treated with 1M HCl (90 mL)
5. filtrationthe resulting precipitate was collected by filtration
6. customdried