HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2196759Generated: October 30, 2026
Ammonium Hydroxide → N-(4-methyl-5-sulfamoylthiazol-2-yl)acetamide
https://huagongshe.com/reaction/2196759
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 2-Acetamido-4-methylthiazole-5-sulfonyl chloride | HCID 96951 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-(4-methyl-5-sulfamoylthiazol-2-yl)acetamide | HCID 3244062 | — |
Reaction Steps
2-Acetamido-4-methylthiazole-5-sulfonyl chloride (0.50 g, 1.96 mmol) was dissolved in THF (7 mL), cooled to 0° C., and concentrated NH4OH (0.7 mL) was added. After 3 hours the reaction was concentrated, diluted with water, and extracted with CHCl3/methanol. The organic layer was dried over Na2SO4. Filtration and concentration gave the product that was used EXAMPLE 11B.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08338466B2 |
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| Source dataset | uspto-grants-2012_12 |
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| ORD ID | ord-a15bda6aa10644fea9986f4ec591e534 |
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| Source note | uspto-grants-2012_12 |
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