HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → HCID 67144994, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | 3-Chlorophenol | HCID 7933 | — |
| Reactant | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Reactant | Benzoic acid, 2,4-difluoro-, ethyl ester | HCID 2737170 | — |
| Solvent | Diglyme | HCID 8150 | — |
| Product | HCID 67144994 | HCID 67144994 | — |
Reaction Steps
Ethyl 2,4-difluorobenzoate (6.0 g), K3PO4 (7.5 g) and 3-chlorophenol (4.1 g) were stirred at 110° C. in diglyme (25 mL) for 24 hours. The mixture was cooled and poured into ether. The solution was washed three times with 1M NaOH solution, and with brine, and dried. The solution was then concentrated. The concentrate was chromatographed on silica gel with 10% ethyl acetate/hexanes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08338466B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-e7b5df5549c6446a9c9c8a6aa79b9d55 |
| Source note | uspto-grants-2012_12 |