Sodium Hydroxide → HCID 67540060, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of EXAMPLE 44G (545 mg) in a mixture of methanol (7.50 ml) and tetrahydrofuran (7.50 ml) was added a solution of sodium hydroxide (269 mg) in water (3.0 ml). The reaction mixture was heated at 50° C. for 18 hours and was concentrated. The residue was mixed with water (100 ml), the pH was adjusted to ca. 7 with 1M aqueous hydrochloric acid, and the mixture was extracted with 10% methanol in methylene chloride (10×50 ml).

Provenance & Evidence