HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2196809Generated: October 29, 2026
Methanol → 3-(3-(1H-pyrrol-1-yl)propyl)-5-methylthiazol-2(3H)-imine
https://huagongshe.com/reaction/2196809
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 2-Amino-5-methylthiazole | HCID 351770 | — |
| Reactant | 1-(3-Bromopropyl)pyrrole | HCID 557119 | — |
| Product | Ammonium Hydroxide | HCID 14923 | — |
| Product | 3-(3-(1H-pyrrol-1-yl)propyl)-5-methylthiazol-2(3H)-imine | HCID 66660838 | 81% |
Reaction Steps
A mixture of 2-amino-5-methylthiazole (0.55 g, 4.8 mmol) and 1-(3-bromopropyl)pyrrole (TCI-US, 1.0 g, 5.3 mmol) was warmed to 85° C. and was stirred for 2 h. The mixture was then cooled to ambient temperature and was purified by flash column chromatography (SiO2, 10% CH3OH in ethyl acetate then 9:1:0.1 CH2Cl2:CH3OH:NH4OH) to give the title compound (0.86 g, 3.9 mmol, 81% yield). MS (DCI/NH3) m/z 222 (M+NH4)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08338467B2 |
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| Source dataset | uspto-grants-2012_12 |
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| ORD ID | ord-45ce09d6f2964b038393ac1b32e853e8 |
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| Source note | uspto-grants-2012_12 |
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