HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → (2-Fluoropyridin-3-yl)methyl methanesulfonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | 2-Fluoro-3-(hydroxymethyl)pyridine | HCID 14761461 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (2-Fluoropyridin-3-yl)methyl methanesulfonate | HCID 86634652 | — |
Reaction Steps
To a solution of (2-fluoropyridin-3-yl)methanol (200 mg, 1.57 mmol) and triethylamine (658 μL, 4.72 mmol) in CH2Cl2 (10 mL) was added methanesulfonyl chloride (269 mg, 2.36 mmol). The reaction mixture was kept at 0° C. for 30 min., poured into water, and the mixture was extracted with CH2Cl2 (2×20 mL). The combined organic layers were dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure. The product was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08338467B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-4e5e8977152d43c0bd6cf82aef445983 |
| Source note | uspto-grants-2012_12 |