HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 2-amino-1-[(2S)-2-(2-benzyltetrazol-5-yl)pyrrolidin-1-yl]-2-cyclohexylethanone;2,2,2-trifluoroacetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | {2-[(S)-2-(2-Benzyl-2H-tetrazol-5-yl)-pyrrolidin-1-yl]-1-cyclohexyl-2-oxo-ethyl}-carbamic acid tert-butyl ester | HCID 59787961 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-amino-1-[(2S)-2-(2-benzyltetrazol-5-yl)pyrrolidin-1-yl]-2-cyclohexylethanone;2,2,2-trifluoroacetic acid | HCID 86601084 | — |
Reaction Steps
To a solution of compound E in DCM (4 mL) is added TFA (4 mL) at 0° C. The solution is stirred at room temperature for 1 hr and dried under vacuum. The crude oil is used directly in the next step without further purification. M+H+=369.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08338440B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-f0b49a952b874e4293bea380f11ec19e |
| Source note | uspto-grants-2012_12 |