Lithium Hydroxide → HCID 62757161, compound

Participants

Reaction Steps

A solution of 2-cyclohexyl-pyrimidine-5-carboxylic acid methyl ester (0.97 g, 4.39 mmol) and aqueous LiOH (1 M, 4.39 mL) MeOH (6 mL) is stirred at room temperature overnight. MeOH is evaporated in vacuo, and the aqueous solution is treated with 3 N HCl to adjust the pH to between 2 and 3. The resulting precipitate is filtered off, washed with water and dried in vacuo to afford 2-cyclohexyl-pyrimidine-5-carboxylic acid (0.2 g, 22%) as a solid. MS: 207 (M+H).

Provenance & Evidence