HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 1-[(5-Chloro-1,3-dimethyl-1H-pyrazol-4-yl)sulfonyl]-4-methyl-5-phenyl-1H-pyrrole-3-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 15-Crown-5 | HCID 36336 | — |
| Reactant | 5-chloro-1,3-dimethyl-1H-pyrazole-4-sulfonyl chloride | HCID 2777126 | — |
| Reactant | 4-Methyl-5-phenyl-1H-pyrrole-3-carbaldehyde | HCID 71362812 | — |
| Product | 1-[(5-Chloro-1,3-dimethyl-1H-pyrazol-4-yl)sulfonyl]-4-methyl-5-phenyl-1H-pyrrole-3-carbaldehyde | HCID 86620766 | — |
Reaction Steps
By a reaction under similar conditions as in Reference Example 65 and using 4-methyl-5-phenyl-1H-pyrrole-3-carbaldehyde (185 mg), sodium hydride (60% in oil, 60 mg), 15-crown-5 (0.30 mL) and (5-chloro-1,3-dimethyl-1H-pyrazol-4-yl)sulfonyl chloride (298 mg), the title compound was obtained as an oil (yield 379 mg, about 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08338462B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-7d19bb38a1c944f4a54108c98c3a1b1d |
| Source note | uspto-grants-2012_12 |