HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl chloroformate → 2′-[[Cyclobutyl[(phenylmethoxy)carbonyl]amino]methyl]-6-methoxy-4′-(trifluoromethyl)[1,1′-biphenyl]-3-acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl chloroformate | HCID 10387 | — |
| Reactant | Cyclobutylamine | HCID 75645 | — |
| Reactant | (2'-Formyl-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid methyl ester | HCID 86633167 | — |
| Product | 2′-[[Cyclobutyl[(phenylmethoxy)carbonyl]amino]methyl]-6-methoxy-4′-(trifluoromethyl)[1,1′-biphenyl]-3-acetic acid | HCID 44159647 | — |
Reaction Steps
{2′-[(Benzyloxycarbonyl-cyclobutyl-amino)-methyl]-6-methoxy-4′-trifluoromethyl-biphenyl-3-yl}-acetic acid (Compound 1-34) was prepared by following the procedures of Example 1 and using the following starting materials: (2′-formyl-6-methoxy-4′-trifluoromethyl-biphenyl-3-yl)-acetic acid methyl ester, cyclobutylamine, and benzyl chloroformate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08338484B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-202cb74ccb2844e686e8d295493b4465 |
| Source note | uspto-grants-2012_12 |