HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-5-(trifluoromethyl)benzaldehyde → (6-Fluoro-2'-formyl-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-5-(trifluoromethyl)benzaldehyde | HCID 7018047 | — |
| Reactant | Methyl 2-(4-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate | HCID 46739456 | — |
| Product | (6-Fluoro-2'-formyl-4'-trifluoromethyl-biphenyl-3-yl)-acetic acid methyl ester | HCID 86633169 | — |
Reaction Steps
Prepared according to the procedure described in Example 1, Step 4, using the following starting materials: 2-bromo-5-trifluoromethyl-benzaldehyde and [4-fluoro-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-acetic acid methyl ester; the isolated product was further purified by preparative HPLC.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08338484B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-cce894c734ba404892313ad3cd2f2d97 |
| Source note | uspto-grants-2012_12 |