Ethanol → Ethyl 2-(3-bromo-4-hydroxyphenyl)acetate

HRID 2197324Notes

Reaction equation

HRID 2197324 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=[O:11])[CH:5]=[CH:6][C:7]=1[OH:8].S(=O)(=O)(O)O.[CH3:18][CH2:19]O>>[CH2:18]([O:11][C:10](=[O:12])[CH2:9][C:4]1[CH:5]=[CH:6][C:7]([OH:8])=[C:2]([Br:1])[CH:3]=1)[CH3:19]

Participants

4

Reactant 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 27696283-Bromo-4-hydroxyphenylacetic acid

Product 1

HCID 18620106Ethyl 2-(3-bromo-4-hydroxyphenyl)acetate

Procedure

(3-Bromo-4-hydroxy-phenyl)-acetic acid (5.6 mmol) in EtOH (20 mL) was treated with sulfuric acid (1 mL) and stirred at room temperature over the weekend. The mixture was concentrated to give the title compound.

Workup

  1. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-6f422760d3ab45c981c862347dca0d0c
Source dataset
uspto-grants-2012_12
Patent number
US08338484B2

Reaction notes

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