2-Bromo-5-nitrobenzoic acid → (2-Bromo-5-nitrophenyl)methanol

HRID 2197328Notes

Reaction equation

HRID 2197328 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:3]=1[C:4](O)=[O:5].O1CCCC1.B>>[Br:1][C:2]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:3]=1[CH2:4][OH:5]

Participants

3

Reactant 2

HCID 2430252-Bromo-5-nitrobenzoic acidHCID 2723981Borane;tetrahydrofuran

Product 1

HCID 18671373(2-Bromo-5-nitrophenyl)methanol

Procedure

To 2-bromo-5-nitrobenzoic acid (5 g, 20 mmol) at 0° C. was added borane tetrahydrofuran complex (1M in THF; 200 mL, 200 mmol), and the reaction was stirred at room temperature overnight. The mixture was quenched with 1N aqueous HCl to give the title compound.

Workup

  1. customThe mixture was quenched with 1N aqueous HCl

Sources & evidence

ORD record
ord-3bf9671d0666498696d29a90a190f3b5
Source dataset
uspto-grants-2012_12
Patent number
US08338484B2

Reaction notes

Loading…