Phosphorus oxychloride → HCID 58326546, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 6-(2,6-dimethyl-phenyl)-pyridazin-3-ol in POCl3 is heated at 80° C. for 2 h. The volatile material is evaporated under reduced pressure and the residue is partitioned between EtOAc and diluted NaOH aqueous solution. The organic layer is separated and the aqueous layer is extracted with EtOAc once. The combined organic extract is washed with brine, dried and concentrated in vacuo. The crude product is purified by flash column (Hexanes/EtOAc 4:1) to give 3-chloro-6-(2,6-dimethyl-phenyl)-pyridazine. 1H NMR: (CDCl3) 7.59 (d, 1H), 7.38 (d, 1H), 7.25 (m, 1H), 7.14 (d, 2H), 2.06 (s, 6H).

Provenance & Evidence