HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2197413Generated: October 29, 2026
Dimethylacetamide → 4-Chlorophthalazin-1-amine
https://huagongshe.com/reaction/2197413
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylacetamide | HCID 31374 | — |
| Reactant | 1,4-Dichlorophthalazine | HCID 78490 | — |
| Reactant | Potassium Fluoride | HCID 522689 | — |
| Product | 4-Chlorophthalazin-1-amine | HCID 6409800 | — |
Reaction Steps
A mixture containing 4 mL of 0.5 M 1,4-dichlorophthalazine in DMA, 2 equivalents of amine and 500 mg of KF is heated in a sealed vial at 100° C. overnight. Purification on silica gel and evaporation provides the desired 1-amino-4-chloro-phthalazine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08338591B2 |
|---|
| Source dataset | uspto-grants-2012_12 |
|---|
| ORD ID | ord-59cf91241667431182bd961e6394945c |
|---|
| Source note | uspto-grants-2012_12 |
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