HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 3-Amino-5-chloro-1,3-dihydro-3-(2-methoxyphenyl)indol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Ethanol, reaction products with ammonia, distn. residues | HCID 22020343 | — |
| Reactant | 5-Chloro-3-hydroxy-3-(2-propoxyphenyl)-indole-2-one | HCID 57466441 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-Amino-5-chloro-1,3-dihydro-3-(2-methoxyphenyl)indol-2-one | HCID 21925414 | — |
Reaction Steps
10 g (32.45 mmol) of the intermediate product 2a were suspended in 100 ml methylene chloride. After the addition of 100 ml 2-molar ethanol ammonia solution, the reaction mixture was stirred for 16 h. After this, everything was poured on to icy water and the organic phase was separated. The aqueous phase was cooled, wherein a white crystallizate formed, which was isolated. 5.7 g of the product were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08338590B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-415ab69707b646358d578f706e879008 |
| Source note | uspto-grants-2012_12 |