Tetrabutylammonium Fluoride → HCID 24803271, compound

Participants

Reaction Steps

38 mg (1 eq.) of the 1-[4-(3-thiophen-2-yl[1,2,4]oxadiazol-5-yl)piperid-1-yl]-2-(4-trimethylsilanyl[1,2,3]triazol-1-yl)ethanone obtained above in the preceding step and 100 μl (1.05 eq.) of tetrabutylammonium fluoride were dissolved in 0.9 ml of THF in a sealed tube, and then refluxed for 1 hour. After cooling to room temperature, the THF was evaporated off and the residue was then purified on silica gel (90/10 CH2Cl2/methanol). 1-[4-(3-Thiophen-2-yl[1,2,4]oxadiazol-5-yl)piperid-1-yl]-2-[1,2,3]triazol-1-ylethanone was obtained in the form of a pale yellow solid, in a yield of 48%.

Provenance & Evidence