Potassium Carbonate → HCID 86617439, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 2-(2-methoxyethoxy)adenine Compound (15) (200 mg, 0.96 mmol) in DMF (5 ml) was added K2CO3 (132 mg 0.96 mmol). Then diethyl (3-bromopropyl)phosphonate (265 μl, 1.44 mmol) was added. The reaction mixture was stirred at 70° C. for 1 h, and the solvent was removed under vacuum. The residue was dissolved in DCM and washed with brine. The aqueous phase was extracted again with DCM. The combined organic layers were dried over Na2SO4, filtered, and concentrated under vacuum. The residue was purified by silica gel chromatography (eluting using a linear gradient of 0-10% MeOH in DCM) to give 293 mg of Compound (19). 1H NMR (CDCl3) δ 1.10-1.16 (m, 6H), δ 1.52-1.59 (m, 2H), δ 1.90-2.09 (m, 2H), δ 3.25 (s, 3H), δ 3.51-3.57 (m, 2H), δ 3.89-3.92 (m, 4H), δ 4.04 (t, 2H), δ 4.28 (t, 2H), δ 6.60 (M, 2H), δ 7.53 (s, 1H); MS: 388.1 (M+H)+, 386.0 (M−1).

Provenance & Evidence