Potassium Carbonate → HCID 68872956, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 6-amino-2-(2-methoxyethoxy)adenine Compound (15) (300 mg, 1.43 mmol) in DMF (3 ml) was added K2CO3. Then (2,3-epoxypropyl)benzene (285 μl, 34 mmol) was added and the reaction mixture was stirred at 70° C. for 5 h. The solvent was removed under vacuum and the residue was washed with brine. The aqueous phase was extracted with DCM and the combined organic layers were dried over Na2SO4, filtered, concentrated, and purified by silica gel chromatography (eluting a linear gradient of 0-10% MeOH in DCM) to give 170 mg of Compound (22). 1H NMR (CDCl3) δ 2.82-2.85 (dd, 2H), δ 3.43 (s, 3H), δ 3.74 (t, 2H), δ 4.00-4.10 (m, 1H), δ 4.25-4.29 (m, 2H), δ 4.42 (t, 2H), δ 5.76 (bs, 2H), δ 7.21-7.34 (m, 5H), δ 7.50 (s, 1H); MS: 494.2 (M+H)+.

Provenance & Evidence