Bromotrimethylsilane → HCID 178496193, compound

Participants

Reaction Steps

Ethyl hydrogen 3-((6-amino-8-hydroxy-2-(2-methoxyethoxy)-9H-purin-9-yl)methyl)phenylphosphonate (K) (10 mg, 0.0236 mmol) was suspended in anhydrous acetonitrile (3 mL). Bromotrimethylsilane (0.2 mL) was added. After stirring at room temperature overnight, the mixture was concentrated under vacuum and treated with water (2 mL). Acetonitrile (1 mL) was added and the product was purified by preparative reverse phase HPLC, yielding 3-((6-amino-8-hydroxy-2-(2-methoxyethoxy)-9H-purin-9-yl)methyl)phenylphosphonic acid (L) (1.5 mg) as a white solid. 1H-NMR (DMSO) δ: 10.0 (s, 1H), 7.64-7.35 (m, 5H), 6.48 (br, 2H), 4.86 (s, 2H), 4.25 (t, J=4.5 Hz, 2H), 3.57 (t, J=4.5 Hz, 2H), 3.25 (s, 3H). MS: 396 (MH+).

Provenance & Evidence