Potassium Carbonate → HCID 57816881, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 6-amino-2-(2-methoxyethoxy)adenine (300 mg, 1.43 mmol) in DMF (3 ml) was added K2CO3 (200 mg, 1.43 mmol). Then 1,2-epoxy-3-phenoxy-propane (321 mg, 2.14 mmol) was added. The reaction mixture was stirred at 70° C. overnight. The solvent was removed and the residue was taken up in CH2Cl2 and washed with water. The aqueous phase was extracted with DCM. The organic layer was dried over NaSO4, filtered, concentrated, and purified by silica gel chromatography, using linear gradient of MeOH in DCM as eluent to give 350 mg product. 1H NMR (CDCl3): δ 3.43 (s, 3H), δ 3.74 (t, 2H), δ 3.90-4.06 (m, 2H), δ 4.30-4.35 (m, 1H), δ 4.30-4.50 (m, 4H), δ 6.00 (bs, 2H), δ 6.88-7.01 (m, 3H), δ 7.27-7.32 (m, 2H), δ 7.70-7.73 (m, 1H); MS: 360.2 (M+1).

Provenance & Evidence