Phenacyl bromide → HCID 57816849, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 6-amino-2-(2-methoxyethoxy)adenine (500 mg, 2.39 mmol) in DMF (5 ml) was added K2CO3 (330 mg, 2.39 mmol). Then 2-bromoacetophenone was added and the reaction mixture was heated to 70° C. with stirring for 30 min. The solvent was removed under vacuum and the residue was washed with brine. The aqueous phase was extracted with DCM and the organic layer was dried over Na2SO4, filtered, concentrated, and purified by silica gel chromatography using linear gradient of MeOH in DCM as eluent. 1H NMR (CDCl3) δ 3.40 (s, 3H), δ 3.72 (t, 2H), δ 4.45 (t, 2H), δ 5.58 (s, 2H), δ 5.67 (bs, 2H), δ 7.53-7.74 (m, 4H), δ 8.03 (s, 1H), δ 8.06 (s, 1H); MS: 328.2 (M+1), 326.0 (M−1).

Provenance & Evidence