Sodium borohydride → HCID 57816766, compound

Participants

Reaction Steps

To a suspension of ethanone prepared in step 1 (60 mg, 0.18 mmol) in THF, was added NaBH4 at room temperature. The reaction was complete after stirring at room temperature for 1 h. The solvent was removed under vacuum and the residue was washed with sat. aq. NaHCO3 solution. The aqueous phase was extracted with DCM. The organic layer was dried over Na2SO4, filtered, concentrated, and purified by silica gel chromatography using a liner gradient of MeOH in DCM as eluent. 1H NMR (CDCl3) δ 3.36 (s, 3H), δ 3.68 (t, 2H), δ 4.07-4.38 (m, 4H), δ 5.12-5.14 (m, 1H), δ 6.36 (bs, 2H), δ 7.26-7.38 (m, 5H), δ 7.51 (s, 1H); MS: 330.1 (M+1).

Provenance & Evidence