Potassium Carbonate → HCID 57816876, compound

Participants

Reaction Steps

To a suspension of 2-methoxylethoxyadenine (500 mg, 2.39 mmol) in DMF (5 ml), was added K2CO3 (329 mg, 2.39 mmol) and ethyl α-bromophenylacetate (460 μl, 2.68 mmol). The reaction mixture was allowed to react at 70° C. for 2 h. The reaction mixture was washed with water and extracted by DCM. The organic later was dried over Na2SO4. The organic layer then was filtered, concentrated and purified by silica gel column, using dichlormethane and MeOH as the solvent in a linear gradient. 1H NMR (CDCl3): δ 1.31 (t, 3H), δ 3.45 (s, 3H), δ 3.78 (t, 2H), δ 4.29-4.33 (m, 2H), δ 4.51 (t, 2H), δ 5.83 (bs, 2H), δ 7.41-7.42 (m, 5H), δ 7.78 (s, 1H); MS: 372.1 (M+H)+, 370.1 (M−1).

Provenance & Evidence