Potassium ethanethioate → HCID 178476933, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (3-(6-Amino-8-bromo-2-(2-methoxy-ethoxy)-purin-9-ylmethyl)-benzyl)-phosphonic acid diethyl ester (50) (180 mg, 0.34 mmol) in DMF (2 ml) was added potassium thioacetate (778 mg, 6.8 mmol). The reaction mixture stirred at 100° C. for 24 h. After cooling to rt, the reaction mixture was filtered and purified by reversed phase prep-HPLC using a linear gradient of acetronitrile in water from 5% to 95%. 1H NMR (DMSO, 300 MHz): (1.08 (t, 3H), (3.00 (d, 2H), (3.25 (s, 3H), (3.58 (t, 2H), (3.77-3.84 (m, 2H), (4.29 (t, 2H), (5.23 (s, 2H), (6.87 (bs, 2H), (7.16-7.28 (m, 4H); 31P NMR (DMSO, 300 MHz): (23.20; MS: 454.1 (M+H)+, 452.0 (M−1).

Provenance & Evidence