反应详情

温度

170 °C

2-chloroadenine (1) (2.81 g, 16.67 mmol) was divided among three microwave vials (10-20 mL), each containing Benzylamine (6 mL), 1-Butanol (8 mL,), and DMSO (1 mL). Each vial was heated to 170° C. for 90 minutes. After reaction completion the solvent was removed by rotary evaporation and triteration with diethylether gave 5.85 g of 71 as an off white solid pure enough for the next step. LCMS: m/z for C12H12N6++H observed 241.2 at 1.45 minutes of a 3.5 minute run, gradient 5-95% CH3CN in H2O.

1. customAfter reaction completion the solvent
2. customwas removed by rotary evaporation and triteration with diethylether