Sodium Hydroxide → HCID 86650129, compound

HRID 2197490Notes

Reaction equation

HRID 2197490 reaction equation
[Cl:1][C:2]1([CH2:8][C:9]([O:11]CC)=[O:10])[NH:6][C:5]([CH3:7])=[CH:4][S:3]1.[OH-].[Na+]>CO>[Cl:1][C:2]1([CH2:8][C:9]([OH:11])=[O:10])[NH:6][C:5]([CH3:7])=[CH:4][S:3]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86650130HCID 86650130, compound

Product 1

HCID 86650129HCID 86650129, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-Chloro-4-methyl-thiazole acetic acid was prepared by hydrolysis of ethyl 2-chloro-4-methyl-thiazole acetate (which was made as described in EP27019), with aqueous sodium hydroxide (1M) in aqueous methanol (1:1), and was used without further purification.

Workup

  1. customwas used without further purification

Sources & evidence

ORD record
ord-752e9f0671e849f68586c6f66429730f
Source dataset
uspto-grants-2012_12
Patent number
US08338598B2

Reaction notes

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