Sodium Bicarbonate → HCID 10797893, compound

Participants

Reaction Steps

To a suspension of 6-morpholin-4-yl-3-nitropyridin-2-amine (200 mg, 0.89 mmol) in acetic acid (3.8 mL) was added iron powder (249 mg, 4.46 mmol). The mixture was stirred at rt for 16 h and then poured slowly into saturated aqueous sodium bicarbonate solution (100 mL). The mixture was extracted with ethyl acetate (3×50 mL), and then the combined organic extracts were washed with brine, dried over sodium sulfate, and concentrated under reduced pressure to provide the desired intermediate (150 mgs, 89%). The crude material was used directly without purification or analysis.

Provenance & Evidence