HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2197539Generated: October 29, 2026
Hydrazine hydrate (1:1) → 1-(5-Bromo-3-phenylpyridin-2-yl)hydrazine
https://huagongshe.com/reaction/2197539
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 5-Bromo-2-fluoro-3-phenylpyridine | HCID 12033012 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 1-(5-Bromo-3-phenylpyridin-2-yl)hydrazine | HCID 58207894 | — |
Reaction Steps
Hydrazine monohydrate (1.76 mL, 13 mmol) was added into a solution of 5-bromo-2-fluoro-3-phenylpyridine (326 mg, 1.29 mmol) in isopropanol (12 mL) at room temperature. The reaction mixture was heated gradually to 82° C. over 5 h and continued to heat overnight, cooled to room temperature and concentrated to give 1-(5-bromo-3-phenylpyridin-2-yl)hydrazine which was used directly in next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08338604B2 |
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| Source dataset | uspto-grants-2012_12 |
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| ORD ID | ord-0c26a59ae69d47be95b3d73bd2a980c5 |
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| Source note | uspto-grants-2012_12 |
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