Hydrochloric Acid → HCID 58207885, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 5-(5-bromo-6-methoxypyridin-3-yl)-N-isopropylthiazol-2-amine (390 mg, 1.18 mmol) in THF (1 mL) was added HCl (4 N, 10 mL) and heated at 90° C. overnight. The mixture was cooled to rt, neutralized with aq NaOH (5 N) and stirred for 1 h. The solid was filtered, rinsed with water and dried to give 3-bromo-5-(2-(isopropylamino)thiazol-5-yl)pyridin-2(1H)-one (359.4 mg, 96%).

Provenance & Evidence