Chloroacetaldehyde → HCID 58207922, compound

HRID 2197567Notes

Reaction equation

HRID 2197567 reaction equation
[NH2:1][C:2]1[N:3]=[CH:4][C:5]([C:14]2[S:15][C:16]([N:19]([CH:27]([CH3:29])[CH3:28])[C:20](=[O:26])[O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[CH:17][N:18]=2)=[N:6][C:7]=1[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.Cl[CH2:31][CH:32]=O>CCO>[CH:27]([N:19]([C:16]1[S:15][C:14]([C:5]2[N:6]=[C:7]([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=3)[C:2]3[N:3]([CH:31]=[CH:32][N:1]=3)[CH:4]=2)=[N:18][CH:17]=1)[C:20](=[O:26])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25])([CH3:29])[CH3:28]

Participants

4

Reactant 2

HCID 33ChloroacetaldehydeHCID 58207883HCID 58207883, compound

Product 1

HCID 58207922HCID 58207922, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
60 °C

Procedure

A solution of tert-butyl 2-(5-amino-6-phenylpyrazin-2-yl)thiazol-5-yl(isopropyl)carbamate (23.7 mg, 0.06 mmol) in EtOH (0.25 mL) was added chloroacetaldehyde (11.8 μL, 50% in water) and the reaction mixture was then heated to 60° C. for 24 h and then concentrated to dryness. The crude product was dried under high vacuum and used without further purification.

Workup

  1. concentrationconcentrated to dryness
  2. dry with materialThe crude product was dried under high vacuum
  3. customused without further purification

Sources & evidence

ORD record
ord-4896620ab9e9473190ab91c4ea23ebba
Source dataset
uspto-grants-2012_12
Patent number
US08338604B2

Reaction notes

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