HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2197568Generated: November 1, 2026
Chloroacetaldehyde → 6-broMo-8-hydroxy-iMidazo[1,2-a] pyridine hydrochloride
https://huagongshe.com/reaction/2197568
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Chloroacetaldehyde | HCID 33 | — |
| Reactant | 2-Amino-5-bromo-3-hydroxypyridine | HCID 11694041 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 6-broMo-8-hydroxy-iMidazo[1,2-a] pyridine hydrochloride | HCID 67007539 | 93.1% |
Reaction Steps
2-Amino-3-hydroxy-5-bromopyridine (Heterocycles, 41:2799 (1995)) (124 mg, 0.65 mmol) was dissolved in EtOH (3 mL) and added chloroacetaldehyde (0.2 mL, 1.3 mmol, 50% in water) and the resulting solution heated at 60° C. overnight. The solvents were then removed and the solids were crystallized from acetone to give 6-bromoimidazo[1,2-a]pyridin-8-ol hydrochloride (151 mg, 92%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08338604B2 |
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| Source dataset | uspto-grants-2012_12 |
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| ORD ID | ord-01159e8c92894e4da2bab05f2cef3e74 |
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| Source note | uspto-grants-2012_12 |
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