HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Isobutylthiazole → 5-Bromo-2-isobutyl-1,3-thiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Isobutylthiazole | HCID 62725 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | Ethyl acetate hexane | HCID 21226206 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-Bromo-2-isobutyl-1,3-thiazole | HCID 20696774 | 87.1% |
Reaction Steps
To a solution of 2-isobutylthiazole (600 mg, 4.25 mmol) in DMF (2 mL) was added N-bromosuccinimide (1.134 g, 6.37 mmol). The mixture was stirred at room temperature for 3 hours then subjected to flash column chromatography using 10% ethyl acetate/hexane to give a yellow oil (815.2 mg, 87% yield). LCMS (Conditions C): Tr 3.51 min; (M+H)': 219.90 (100%), 221.90 (100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08338604B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-c06ef94779544039aaed4cc7cded43bc |
| Source note | uspto-grants-2012_12 |