4-Fluorobenzonitrile → HCID 59717848, compound

HRID 2197626Notes

Reaction equation

HRID 2197626 reaction equation
F[C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.[CH2:10]([NH:17][CH2:18][CH2:19][C:20]1[CH:25]=[CH:24][C:23]([OH:26])=[CH:22][CH:21]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>>[CH2:10]([NH:17][CH2:18][CH2:19][C:20]1[CH:21]=[CH:22][C:23]([O:26][C:2]2[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=2)=[CH:24][CH:25]=1)[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 145174-FluorobenzonitrileHCID 30425724-(2-(Benzylamino)ethyl)phenol

Product 1

HCID 59717848HCID 59717848, compound

Procedure

Reaction of 4-fluorobenzonitrile with the compound of Example 4, step 1 following the procedure, of Example 1, step 2. affords the title compound, 4-[4-(2-Benzylamino-ethyl)-phenoxy]-benzonitrile, (2.7 g): 1H NMR (CDCl3, 300.00 MHz): 7.65-7.58 (m, 2H), 7.41-7.25 (m, 7H), 7.06-6.98 (m, 4H), 3.86 (s, 2H), 3.01-2.83 (m, 4H), m/z=328.9 (M+1).

Sources & evidence

ORD record
ord-47c4897df20b46478ec1908d07358756
Source dataset
uspto-grants-2012_12
Patent number
US08338611B2

Reaction notes

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