2,2-Dimethoxypropane → HCID 68972378, compound

Participants

Reaction Conditions

Reaction Steps

(1S,2S)-(2-hydroxy-1-phenyl-but-3-enyl)carbamic acid t-butyl ester is dissolved in an aromatic solvent. 2,2-Dimethoxypropane is added at a temperature in the range of about 20-40° C. followed by addition of pyridinium p-toluene sulfonate. The reaction mixture is heated to about 70-95° C. and stirred at the same temperature for about 1-5 hours. The reaction mixture is cooled to about 30 to 45° C., neutralized with pyridine, and concentrated under reduced pressure to get (4S,5R)-2,2-dimethyl-4-phenyl-5-vinyl-oxazolidine-3-carboxylic acid t-butyl ester in a semi solid form, which is optionally further purified by column chromatography, such as using petroleum ether and ethyl acetate as solvents.

Provenance & Evidence