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Methyl 4-nitrobutyrate → 8-Benzyloxy-5-hydroxy-4-nitrooctanoic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl 4-nitrobutyrate | HCID 25604 | — |
| 反応物 | 4-Benzyloxybutanal | HCID 231559 | — |
| 反応物 | Sparteine | HCID 644020 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 8-Benzyloxy-5-hydroxy-4-nitrooctanoic acid methyl ester | HCID 59336227 | — |
反応手順
4-benzyloxybutanal (1.463 g, 8.2 mmol), methyl-4-nitrobutyrate (1.29 g, 8.8 mmol) and (−)-sparteine (206 mg, 0.88 mmol) are combined and stirred at RT for 6 hours. EtOAc (5 mL) is added, and the solution is filtered through silica. The solvent is removed in vacuo to yield a pale yellow oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08338620B2 |
| 出典データセット | uspto-grants-2012_12 |
| ORD ID | ord-9d4ca1a4aa13472e813b368569984535 |
| 出典メモ | uspto-grants-2012_12 |