反应详情

温度

60 °C

A mixture of powdered caesium carbonate (9.0 g, 27.4 mmol, 5 equiv.), ethyl-4-aminobutyrate (IVb) (1.85 g, 11.0 mmol, 2 equiv.) and methanesulfonic acid (R)-1-carbamoyl-propyl ester (IIi) (1.0 g, 5.5 mmol, 1 equiv.) in acetonitrile (20 ml, 20 vol.) is heated to 60° C. for 16 hours. The mixture is then filtered and the cake rinsed with acetonitrile (50 ml). Combined filtrates are concentrated to dryness under reducd pressure. The crude methyl-(R)-4-(1-carbamoylpropylamino)butyrate is used directly in the next step.

1. filtrationThe mixture is then filtered
2. washthe cake rinsed with acetonitrile (50 ml)
3. concentrationCombined filtrates are concentrated to dryness under reducd pressure